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FLASH GENE
Symbol DNAJC24 contributors: mct/npt - updated : 29-12-2015
HGNC name DnaJ (Hsp40) homolog, subfamily C, member 24
HGNC id 26979
Location 11p13      Physical location : 31.391.376 - 31.454.381
Synonym name
  • zinc finger, CSL-type containing 3
  • DPH4 homolog (JJJ3, S. cerevisiae)
  • DPH4, JJJ3 homolog
  • diphthamide biosynthesis protein 4
  • Synonym symbol(s) ZCSL3, DPH4, JJJ3, 1700030A21Rik
    DNA
    TYPE functioning gene
    STRUCTURE 63.02 kb     5 Exon(s)
    regulatory sequence Promoter
    cytosine-phosphate-guanine/HTF
    text structure
  • a single CpG island, which spans the transcriptional start site
  • MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 3000 17 149 - 2012 22509046
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepancreas exocrine   highly
     salivary gland   highly
    Endocrineadrenal gland   moderately
    Urinarybladder   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  predominantly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a DNAJ domain
  • a DPH-type zinc finger domain
  • a conserved J-domain and a CSL-domain connected via a flexible linker-helix
  • HOMOLOGY
    interspecies ortholog to Yeast Jjj3
    homolog to rattus Dph4 (83.6 pc)
    homolog to murine Dnajc24 (84.9 pc)
    Homologene
    FAMILY
  • DPH4 family
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    text localized to the cytoskeleton (Webb 2008)
    basic FUNCTION
  • stimulating the ATPase activity of several Hsp70-type chaperones
  • involved in synthesis of diphthamide in translation elongation factor-2 (EEF2)
  • type III J-protein playing a vital role in diphthamide biosynthesis and normal development
  • exhibits a unique ability to bind iron in tetrahedral coordination geometry through cysteines of its CSL-domain
  • contains a DNAJ domain and may function as a cochaperone
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • binding to heat shock protein
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS