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FLASH GENE
Symbol CFAP65 contributors: mct - updated : 04-07-2017
HGNC name cilia and flagella associated protein 65
HGNC id 25325
Corresponding disease
MIMAF4 Male Infertility with multiple Morphological Abnormalities of the sperm Flagella 4
Location 2q35      Physical location : -
Synonym name coiled-coil domain containing 108
Synonym symbol(s) DKFZp434O0527, MGC35338, CCDC108
DNA
TYPE functioning gene
STRUCTURE 40.30 kb     35 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
35 - 5992 217 1925 - 2012 22761584
4 - 2318 - 164 - 2012 22761584
12 - 3287 - 730 - 2012 22761584
13 - 3336 - 784 - 2012 22761584
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousnerve    
Reproductivemale systemtestis  specific Homo sapiens
Respiratoryrespiratory tracttrachea   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a coiled-coil domain
  • a MSP (major sperm protein) domain, that is present in sperm-specific proteins
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • roles of CFAP65 in spermatogenesis and flagellar development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • potential interaction and/or inter-regulation between CFAP65 and CFAP47 during spermiogenesis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MIMAF4
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Rose-comb mutation in chickens can cause the partial loss of function of Cfap65 and lead to defective sperm motility in male homozygotes
  • Cfap65 is expressed specifically in sexually mature male mice but is absent in juvenile mice