Selected-GenAtlas references SOURCE GeneCards NCBI Gene Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol IFTAP contributors: mct - updated : 24-05-2022
HGNC name intraflagellar transport associated protein
HGNC id 25142
Location 11p12      Physical location : -
Synonym name
  • hypothetical protein LOC119710
  • protein HEPIS
  • chromosome 11 open reading frame 74
  • Synonym symbol(s) FLJ38678, HEPIS, C11orf74, NWC
    DNA
    TYPE functioning gene
    STRUCTURE 64.77 kb     1 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1035 - 221 - 2019 30476139
    4 - 813 - 147 - 2019 30476139
    6 - 915 - 221 - 2019 30476139
    6 - 693 - 147 - 2019 30476139
    6 - 866 - 221 - 2019 30476139
    4 - 644 - 147 - 2019 30476139
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Endocrineneuroendocrinepituitary  highly
     parathyroid    
    Reproductivemale systemtestis    Mus musculus
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text umbilical cord
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three strongly conserved domains not found in any other known protein
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microfilament
    basic FUNCTION
  • might play limited roles involving cilia
  • plays likely an important role in spermatogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • IFTAP interacts with the IFT-A complex via the IFT122 subunit and is accumulated at the distal tip in the absence of an IFT-A subunit TTC21B
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • sperm of knockout murine males fail to successfully compete with control sperm