protein
| interacts with the C-terminal half of the folliculin tumor suppressor protein and with an important nutrient- and energy-sensing molecule, AMPK, a negative regulator of FRAP1 |
|
FLCN retains an ability to stably bind to FNIP2 during apoptosis , and FNIP2 may interact with folliculin and AMPK in a specific manner during the course of apoptosis |
|
proapoptotic function of FNIP2 may be regulated by AMPK and FLCN through stabilization of FNIP2 itself |
|
FLCN-GABARAP association is modulated by the presence of either folliculin-interacting protein FNIP1 or FNIP2 and further regulated by ULK1 |