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FLASH GENE
Symbol ANAPC15 contributors: mct - updated : 22-01-2013
HGNC name anaphase promoting complex subunit 15
HGNC id 24531
Location 11q13.4      Physical location : -
Synonym name
  • hypothetical protein LOC25906
  • chromosome 11 open reading frame 51
  • Synonym symbol(s) HSPC020, DKFZP564M082, C11orf51, APC15
    DNA
    TYPE functioning gene
    STRUCTURE 3.19 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 882 14 121 - 2011 21926987
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepancreas exocrine    
    Endocrineneuroendocrinepituitary   
     pancreas    
    Lymphoid/Immunetonsils    
    Reproductivefemale systemovary   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to yeast Mnd2
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • required for the turnover of the APC/C(anaphase-promoting complex, or cyclosome) co-activator CDC20 and release of mitotic checkpoint proteins complexes during spindle assembly checkpoint signalling
  • mediates the constant turnover of CDC20 and mitotic checkpoint proteins complexes on the APC/C to allow the spindle assembly checkpoint to respond to the attachment state of kinetochores.
  • ANAPC15 negatively regulate APC/C coactivators and report generation of recombinant human APC/C
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS