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FLASH GENE
Symbol CACUL1 contributors: mct - updated : 05-04-2018
HGNC name CDK2-associated, cullin domain 1
HGNC id 23727
Location 10q26.11      Physical location : -
Synonym name
  • cullin
  • CDK2-associated, cullin domain 1
    • Synonym symbol(s) FLJ40409, MGC33215, C10orf46, CAC1
    DNA
    TYPE functioning gene
    STRUCTURE 74.26 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 6758 41 369 - 2012 2298268
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumear   highly
    Lymphoid/Immunelymph node    
    Reproductivefemale systemovary   
     female systemuterus   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a CoRNR box
    • HOMOLOGY
    Homologene
    FAMILY
  • cullin family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • had an oncogene-like function related to cell cycle regulation
  • is an important factor for the protection of cells against APP toxicity and oxidative stress
  • is a novel type of RARA coregulator that interacts with RARA and inhibits its transcriptional activity
  • is a novel corepressor of RARA that cooperates with HDACs and is involved in the regulation of RA-induced cellular differentiation
  • impaired recruitment of ESR1 and KDM1A to the ESR1-responsive promoter, leading to greater H3K9me3 accumulation
  • CACUL1 function in human adipose-derived stem cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • cooperates with histone deacetylases (HDACs) to suppress RARA, probably by associating with HDAC
  • associated with histone demethylase KDM1A and suppressed KDM1A-enhanced ESR1 activity
  • associated with KDM1A, functions as an ESR1 corepressor, implicating a potential antitumor target in ESR1-positive breast cancer
  • CACUL1/CAC1 is a positive regulator of the NFE2L2 pathway
  • directly associates with AR and suppresses AR transcriptional activity
  • CACUL1 is a novel regulator that negatively controls TP53 activity through the regulation of PML SUMOylation
  • CACUL1 tightly regulates PPARG signaling through the mutual opposition between SIRT1 and KDM1A, providing insight into its potential use for anti-obesity treatment
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    expression level of CACUL1 in the hippocampus of Alzheimer disease patients was significantly lower than that of normal controls
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    CACUL1 impairs KDM1A-mediated activation of AR, thereby implicating it as a potential antitumor target in prostate carcinoma
    ANIMAL & CELL MODELS