basic FUNCTION
| promoting TP53-mediated apoptosis through specific inhibition of SIRT1 |
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may be an important regulator of heterochromatin formation and genomic stability by disrupting the SUV39H1-SIRT1 complex and inactivating both enzymes |
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involved in cell proliferation, apoptosis and histone modification, all processes important for regulating tumorigenesis |
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role in regulating ESR2-dependent gene expressions |
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its expression inhibits the transactivation of the SIRT1 promoter mediated by full-length BRCA1 |
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may modulate the cellular functions of BRCA1 and have important implications in the understanding of carcinogenesis in breast tissue |
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regulator of some nuclear receptors, the methyltransferase SUV39H1, and the NAD-dependent deacetylase SIRT1 |
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endogenous inhibitor of HDAC3 |
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new regulator of HDAC3 and is a negative regulator of two key distinct deacetylases, SIRT1 and HDAC3 |
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KIAA1967 and SIRT1 play reciprocal roles as major regulators of ESR1 activity, by regulating DNA binding by ESR1 and by regulating co-activator synergy |
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is a large, predominantly nuclear, multidomain protein that modulates gene expression by inhibiting several epigenetic modifiers, including the deacetylases SIRT1 and HDAC3, and the methyltransferase SUV39H1 |
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CCAR2 and CCAR1 are largely disordered proteins that have evolved from one common ancestor |