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FLASH GENE
Symbol WDR83 contributors: mct/npt - updated : 26-03-2019
HGNC name WD repeat domain 83
HGNC id 32672
Location 19p13.13      Physical location : 12.777.617 - 12.786.645
Genatlas name mitogen-activated protein kinase organizer 1
Synonym name MAPK organizer 1
Synonym symbol(s) MGC4238, MORG1
DNA
TYPE functioning gene
STRUCTURE 9.03 kb     11 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 1476 34.3 315 - 2013 23439680
9 - 1219 34.3 315 - 2013 23439680
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel     Homo sapiens
Nervousbrain     Homo sapiens
 nerve   highly
Visualeye   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Cardiovascularendothelial cell Homo sapiens
Nervousglia Homo sapiens
Nervousneuron Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven WD-repeat domains
  • HOMOLOGY
    Homologene
    FAMILY
  • WD-40 protein family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,nucleus
    text in the spliceosome
    basic FUNCTION
  • acting as a molecular scaffold for hypoxia-inducible factor prolyl hydroxylase 3 (EGLN3)
  • modular scaffold regulating ERK signaling
  • WDR83 and DHPS were capable of forming an RNA duplex at overlapping 3 prime untranslated regions and this duplex increased their mutual stability, which was required for the bidirectional regulation
  • WDR83 scaffold could represent the missing link between innate immunity and inflammation
  • play a scaffold function in the MAPK and/or the PHD3 signalling paths
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • specifically interacts with PHD3 most likely by acting as a molecular scaffold (Hopfer 2006)
  • binding partner of the extracellular signal-regulated kinase (ERK) pathway scaffold protein MAP2K1IP1
  • attenuates expression of HIF1A by activating or stabilizing of prolyl-hydroxylase 3 (PHD3)
  • WDR83 interacts with the apical transmembrane protein CRB3 to promote PARD6A- Atypical protein kinase C (aPKC) binding to CRB3, which is reinforced with the apically localized small GTPase CDC42
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in human brain tissue with ischemic damage
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    miscelleaneousurinarychronic kidney disease
    therapeutical manipulation of WDR83 may be an interesting novel target to prevent hypoxia-associated renal damage
    ANIMAL & CELL MODELS
  • Morg1 heterozygosity protects against histological renal damage and shows anti-inflammatory effects in a murine endotoxemia model through modulation of HIF-2alpha stabilisation and/or simultaneous inhibition of the NFKB1 signalling