basic FUNCTION
| protein of the interphase nucleolus |
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is expressed and functional during skeletal development because loss of P3H4 results in a progressive osteopenia that affects both trabecular and cortical bone |
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like its related family member CRTAP, is an important modulator of bone homeostasis, acting as a negative regulator of osteoclastogenesis |
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P3H1 preferentially 3-hydroxylates proline at a single site in collagen type I chains, whereas P3H2 is responsible for 3-hydroxylating multiple proline sites in collagen types I, II, IV, and V |
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P3H4 is significantly involved in several types of human cancer |
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tumour-associated autoantigen in patients with prostate cancer |
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is involved in the post-translational modification of fibrillar collagens |
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role for the Leprecans in the post-translational modification of collagens expressed in the stroma of the reproductive organs |