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FLASH GENE
Symbol SGSM3 contributors: - updated : 31-08-2007
HGNC name small G protein signaling modulator 3
HGNC id 0
Location 22q13.1-q13.2      Physical location : 40.766.594 - 40.806.293
Synonym name
  • RUN and SH3 containing 3
  • RUN and TBC1 domain containing 3
  • merlin-associated protein
  • Synonym symbol(s) MAP, RUSC3, RUTBC3
    DNA
    TYPE functioning gene
    STRUCTURE 39.00 kb     22 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • TBC, SH3, and RUN domains, thereby implicating its role in the Ras-like GTPase signal pathways
  • RAPID motifs
  • HOMOLOGY
    Homologene
    FAMILY SGSM family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • may play a cooperative role in the merlin-mediated growth suppression of cells
  • involved in several processes of intracellular transportation by interacting with distinct RAB members
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with Merlin (RUN domain of SGSM3 and the C-terminus of merlin appeared to be responsible for their interaction)
  • bind to RAP and RAB family proteins
  • having GAP activity specific for RAB5 and also binds strongly to RAB8
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS