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FLASH GENE
Symbol LYZL4 contributors: mct - updated : 27-03-2020
HGNC name lysozyme-like 4
HGNC id 28387
Location 3p22.1      Physical location : 42.438.576 - 42.452.065
Synonym name
  • lysozyme A
  • lysozyme-4
  • Synonym symbol(s) LYC4, MGC26768, LYZA, 1810009N24Rik
    DNA
    TYPE functioning gene
    STRUCTURE 51.03 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 890 - 146 - 2005 16014814
    5 - 909 - 146 - 2005 16014814
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis    Homo sapiens
     male systemmale genital tract    Homo sapiens
    cell lineage
    cell lines
    fluid/secretion sperm
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 19 AAs in signal peptide
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
    intracellular,nucleus
    basic FUNCTION
  • plays a physiological role in male reproduction
  • may have a role in sperm function, innate immunity and other physiological process as well
  • role for LYZL2, LYZL4, LYZL6 in sperm function
  • role of SPACA3 and LYZL4 in fertilization
  • contribute likely to fertilization but show no bacteriolytic activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SPACA3, LYZL4 and SPACA5 possess hyaluronan binding ability
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    downregulated in asthenozoospermic condition in human
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • biomarker for male fertility
  • Therapy target
    ANIMAL & CELL MODELS