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FLASH GENE
Symbol SLC25A33 contributors: mct - updated : 25-11-2020
HGNC name solute carrier family 25, member 33
HGNC id 29681
Location 1p36.22      Physical location : 9.599.527 - 9.642.830
Synonym name PNC1 protein, mitochondrial carrier protein
Synonym symbol(s) BMSC-MCP, MGC4399
DNA
TYPE functioning gene
STRUCTURE 45.71 kb     7 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 3865 - 321 - 2014 25320081
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Nervousbraindiencephalonepithalamus highly
 brainbasal nucleicorpus callosum highly
 nervecranial nerve  highly
Urinarykidney   highly
Visualeyeretina    Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Visualcone photoreceptor Homo sapiens
Visualrod photoreceptor Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four EF-hand domains
  • three solcar repeats
  • six alpha-helical membrane spanning regions
  • HOMOLOGY
    intraspecies homolog to SLC25A36
    Homologene
    FAMILY mitochondrial carrier family
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • calcium-dependent mitochondrial solute carrier
  • phylogenetically conserved and widely expressed mitochondrial carrier protein which perhaps associates with mitochondrial oxidative phosphorylation
  • main physiological role of SLC25A33 and SLC25A36 is to import/export pyrimidine nucleotides into and from mitochondria, i.e. to accomplish transport steps essential for mitochondrial DNA and RNA synthesis and breakdown
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS mitochondrial transport
    text oxidative phosphorylation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS