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FLASH GENE
Symbol TBC1D3E contributors: mct - updated : 16-11-2020
HGNC name TBC1 domain family, member 3E
HGNC id
Location 17q12      Physical location : -
Synonym name
  • Prostate cancer gene 17 protein
  • Protein TRE17-alpha
  • Rab GTPase-activating protein PRC17
  • TBC1 domain family member 3
  • TBC1 domain family member-like
  • Synonym symbol(s) PRC17, TBC1D3, TBC1D3A, TBC1DE3, DKFZp434P2235
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text 8 paralogues clustered in 17q12
    STRUCTURE 20.46 kb     14 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 2082 - 549 - 2006 16625196
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a TBC domain
  • a GTPase-activating protein (GAP) catalytic core motif found in various Rab/Ypt GAPs, including RN-Tre
  • HOMOLOGY
    intraspecies paralog to TBC1D3
    Homologene
    FAMILY
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • likely cells overexpressing TBC1D3E acquired the property of reduced contact inhibition
  • is likely a potent transforming gene in vivo and GAP activity is required for its transforming function
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts directly with RAB5 and stimulates its GTP hydrolysis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    highly overexpressed in approximately one-half of metastatic prostate tumors
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS