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FLASH GENE
Symbol TXNDC11 contributors: mct - updated : 30-08-2022
HGNC name thioredoxin domain containing 11
HGNC id 28030
Location 16p13.13      Physical location : 11.772.942 - 11.836.648
Synonym name EF-hand binding protein 1
Synonym symbol(s) EFP1
DNA
TYPE functioning gene
STRUCTURE 63.00 kb     12 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 2873 - 506 - 2020 32065582
11 - 2986 - 744 - 2020 32065582
11 - 3003 - 506 - 2020 32065582
12 - 3116 - 958 - 2020 32065582
12 - 3197 - 985 - 2020 32065582
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
 mouthtongue  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two thioredoxin domains
  • five thioredoxin (Trx)-like domains
  • HOMOLOGY
    Homologene
    FAMILY thioredoxin-related protein family
    CATEGORY
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • may act as a redox regulator involved in DUOX proteins folding
  • could be one of the partners in the assembly of the multiprotein complex constituting the thyroid H(2)O(2) generating system but is certainly not sufficient to permit H(2)O(2) generation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the cytoplasmic part of DUOX1 and DUOX2
  • interacts with TPO and CYBA
  • EDEM1, EDEM2 associate with oxidoreductases, protein disulfide isomerase, and especially TXNDC11, enhancing mannosidase activity on glycoproteins but not on free N-glycans
  • EDEM2 was stably disulfide-bonded to TXNDC11, an endoplasmic reticulum protein containing five thioredoxin (Trx)-like domains
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in glioma, and high TXNDC11 expression was associated with poor overall survival (OS) and worse clinical prognostic variables
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • high expression of TXNDC11 may predict unfavorable prognosis of glioma patients
  • Therapy target
    ANIMAL & CELL MODELS