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FLASH GENE
Symbol ADIG contributors: mct - updated : 15-09-2022
HGNC name adipogenin
HGNC id 28606
Location 20q11.23      Physical location : 37.209.837 - 37.217.104
Synonym name
  • small adipocyte factor 1
  • Synonym symbol(s) MGC149650, MGC39724, RP5-1100H13.2, SMAF1, KIAA1219
    DNA
    TYPE functioning gene
    STRUCTURE 7.27 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 727 9 80 - -
    3 - - - - - -
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    not specificadipocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • adipogenin family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • involved in adipocyte tissue function or regulation
  • is a novel small protein endogenous to adipocytes and its expression is closely tied to PPARG-mediated signals and the adipocyte phenotype (
  • does not have a major role in adipocyte triglyceride accumulation and lipolysis (
  • increased during the adipocyte differentiation
  • adipocyte-enriched transmembrane protein
  • ADIG is likely required for adipogenesis, likely having an additional impact on the regulation of leptin secretion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Adig-/- mice are leaner than wild-type mice when fed a high-fat diet