SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,organelle,endosome
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| intracellular,cytoplasm,cytosolic,vesicle
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| intracellular,cytoplasm,cytoskeleton
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text
| trans-elements of the Golgi and peripheral endosomes, clathrin-coated vesicles |
basic FUNCTION
| may play a role in autophagy, and autophagic capacity may be compromised in cancers (Proikas-Cezanne 2007) |
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may regulate the trafficking of proteins involved in the |
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mannose-6-phosphate receptor (MPR) recycling pathway |
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role for WIPI1 in the biogenesis of melanosomes, cell type-specific lysosome-related organelles |
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distinct role for WIPI1 and CRTC1 signaling in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is distinct from starvation-induced autophagy |
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WIPI1 and WIPI2 as novel protein components of autophagosomes, and of membrane sites from which autophagosomes might originate (ER, PM, Golgi area) |
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WIPI proteins function as essential phosphatidylinositol 3-phosphate (PtdIns3P) effectors at the nascent autophagosome |
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regulates likely mitochondrial oxidative signaling and non-canonical autophagy in cardiac myocytes |
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WIPI1 specifically acts in the formation and fission of tubulo-vesicular endosomal transport carriers |
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WIPI1 supports autophagy and protein exit from endosomes by different modes of action |