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FLASH GENE
Symbol MYLK3 contributors: mct - updated : 01-02-2017
HGNC name myosin light chain kinase 3
HGNC id 29826
Location 16q11.2      Physical location : 46.736.195 - 46.782.221
Synonym name
  • cardiac-MyBP-C associated Ca/CaM kinase
  • myosin light chain kinase
  • cardiac-MyBP-C-associated Ca/CaM kinase
  • MLCK protein 2
  • Synonym symbol(s) MGC126319, MGC126320, MLCK, MLCK2, caMLCK
    EC.number 2.7.11.18
    DNA
    TYPE functioning gene
    STRUCTURE 46.03 kb     13 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 7998 88.4 819 - Chan (2008)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheartatrium  specific
     heartventricle  specific
    Hearing/Equilibriumear   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • protein kinase superfamily
  • CAM Ser/Thr protein kinase family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text diffusely localized in the cytoplasm of cardiomyocytes (Chan 2008)
    basic FUNCTION
  • likely a new regulator of MYL2 phosphorylation, sarcomere organization, and cardiomyocyte contraction (Chan 2008)
  • in addition to CAMK2A contributes to phosphorylation of regulatory light chain in cardiomyocytes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other highly regulated by the cardiac homeobox protein NKX2-5 in neonatal cardiomyocytes (Chan 2008)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in heart failure tissue compared with control tissue (Chan 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS