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FLASH GENE
Symbol GPR174 contributors: mct - updated : 20-09-2014
HGNC name G protein-coupled receptor 174
HGNC id 30245
Location Xq21.1      Physical location : 78.426.468 - 78.427.726
Synonym name putative purinergic receptor FKSG79
Synonym symbol(s) FKSG79, GPCR17, LYPSR3
DNA
TYPE functioning gene
STRUCTURE 1.26 kb     1 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 1258 - 333 - 2014 24891334
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
interspecies homolog to murine Gpr174 (88.3pc)
Homologene
FAMILY G-protein coupled receptor 1 family
CATEGORY receptor membrane G
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • may have a purinergic nucleotide receptor activity
  • negatively regulates immune-cell proliferation by increasing intracellular cAMP
  • may play important roles in the central nervous system as a lysophosphatidylserine (LysoPS) receptor
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to Graves disease
    Variant & Polymorphism SNP
  • rs3827440 associated to Graves disease
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS