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FLASH GENE
Symbol LARP4 contributors: mct - updated : 07-03-2022
HGNC name La ribonucleoprotein domain family, member 4
HGNC id 24320
Location 12q13.12      Physical location : 50.794.591 - 50.873.788
Synonym name
  • La-related protein 4
  • c-Mpl binding protein
  • Synonym symbol(s) PP13296, MGC74631, DKFZp686E039
    DNA
    TYPE functioning gene
    STRUCTURE 79.14 kb     16 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 6111 - 582 - 2020 32744499
    16 - 6537 80 724 - 2020 32744499
  • isoform a
  • 16 - 6533 81 723 - 2020 32744499
  • using an alternate in frame exon
  • isoform b
  • 15 - 6323 72 653 - 2020 32744499
  • lacking an alternate in frame exon
  • isoform c
  • 10 - 1681 - 445 - 2020 32744499
    15 - 6324 - 653 - 2020 32744499
    16 - 6526 - 714 - 2020 32744499
    17 - 6487 - 654 - 2020 32744499
    16 - 6277 - 583 - 2020 32744499
    16 - 6217 - 563 - 2020 32744499
    16 - 6274 - 582 - 2020 32744499
    17 - 6505 - 654 - 2020 32744499
    17 - 6530 - 654 - 2020 32744499
    17 - 6317 - 583 - 2020 32744499
    16 - 6459 - 730 - 2020 32744499
    15 - 6246 - 659 - 2020 32744499
    15 - 6387 - 706 - 2020 32744499
    15 - 6319 - 558 - 2020 32744499
    12 - 1654 - 375 - 2020 32744499
    14 - 6106 - 487 - 2020 32744499
    14 - 6106 - 487 - 2020 32744499
    15 - 6157 - 583 - 2020 32744499
    10 - 3258 - 374 - 2020 32744499
    10 - 3045 - 303 - 2020 32744499
    12 - 1694 - 375 - 2020 32744499
    16 - 6217 - 563 - 2020 32744499
    15 - 6225 - 652 - 2020 32744499
    16 - 6370 - 654 - 2020 32744499
    16 - 6370 - 654 - 2020 32744499
    14 - 6490 - 654 - 2020 32744499
    15 - 6456 - 729 - 2020 32744499
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node    
    Nervousnerve    
    Reproductivefemale systembreastmammary gland  
    Urinarybladder    
     kidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one HTH La-type RNA-binding domain
  • a PAM2 motifs with variable affinities for the MLLE domain of PABPC1
  • HOMOLOGY
    Homologene
    FAMILY
  • LARP family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • is a La-related RNA-binding protein implicated in regulating mRNA translation
  • regulates cancer cell migration and invasion
  • LARP4 is a posttranscriptional regulator of ribosomal protein production in mammalian cells, suggesting that this activity can be controlled by tRNA levels
  • likely LARP4 opposes deadenylation by stabilizing PABPC1 on mRNA poly(A) tails
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • LARP1 and LARP4 bind and protect mRNA 3' poly(A) tails from deadenylases through close contact with PABPC1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS