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FLASH GENE
Symbol L3MBTL4 contributors: mct - updated : 15-02-2022
HGNC name l(3)mbt-like 4 (Drosophila)
HGNC id 26677
Location 18p11.31      Physical location : 5.954.705 - 6.414.910
Genatlas name lethal(3)malignant brain tumor-like protein 4
Synonym symbol(s) FLJ35936, HsT1031
DNA
TYPE functioning gene
STRUCTURE 460.56 kb     17 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
19 - 3495 - 614 - 2010 20698951
20 - 3576 - 623 - 2010 20698951
17 - 3308 - 488 - 2010 20698951
19 - 3549 - 614 - 2010 20698951
17 - 3401 - 488 - 2010 20698951
20 - 3535 - 623 - 2010 20698951
16 - 2628 - 497 - 2010 20698951
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel   predominantly Homo sapiens
Digestiveintestinelarge intestinecolon  
 liver    
Lymphoid/Immunespleen    
Reproductivefemale systemovary   
 male systemtestis  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularsmoothvessel predominantly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY receptor membrane
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • may be involved in cell adhesion and platelet activation
  • critical contributor to the development and progression of hypertension
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MAPK14 was required for phenotype changes of VSMCs induced by L3MBTL4 in hypertension
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in breast tumors (
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    miscelleaneoushypertension 
    novel target for therapeutic intervention
    ANIMAL & CELL MODELS