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FLASH GENE
Symbol YPEL3 contributors: np/ - updated : 26-05-2006
HGNC name yippee-like 3 (Drosophila)
HGNC id 18327
Location 16p11.2      Physical location : 30.103.635 - 30.107.537
Synonym name
  • yippee-like 3
  • protein yippee-like 3
  • Synonym symbol(s) MGC10500, FKSG5
    DNA
    TYPE functioning gene
    STRUCTURE 3.90 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 940 - 119 - -
    4 - 1588 - 157 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen   highly
    Reproductivefemale systemplacenta  highly
    Respiratoryrespiratory tractlarynx  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to murine Suap
    Homologene
    FAMILY
  • yippee family
  • CATEGORY regulatory , tumor suppressor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    text localized to the centrosome and nucleolus during interphase and at several dot-like structures around the mitotic apparatus during mitotic phase
    basic FUNCTION
  • playing an important roles in the cell division and in the maintenance of life
  • activates cellular senescence downstream of TP53
  • tumor suppressor, which upon induction triggers a permanent growth arrest in human tumor and normal cells
  • possess a closely related function in the cell division cycle
  • CELLULAR PROCESS cell life
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TP53-regulated gene (YPEL3 expression induced by DNA damage leads to TP53 recruitment to a cis-acting DNA response element located near the human YPEL3 promoter)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in ovarian carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS