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FLASH GENE
Symbol HECTD2 contributors: mct/npt - updated : 17-08-2009
HGNC name HECT domain containing 2
HGNC id 26736
Location 10q23.32      Physical location : 93.170.095 - 93.274.520
Synonym name HECT domain containing 2, isoform a
Synonym symbol(s) FLJ37306, FLJ16050
EC.number 6.3.2.-
DNA
TYPE functioning gene
STRUCTURE 104.42 kb     21 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
21 - 4826 87 776 - Deloukas (2004)
21 - 1726 22 207 - Deloukas (2004)
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Hearing/Equilibriumear    
Reproductivefemale systembreastmammary gland  
 male systemtestis   
Urinarybladder    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connective    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
basic FUNCTION
  • E3 ubiquitin ligase, having an ubiquitin-protein ligase activity
  • CELLULAR PROCESS protein
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other heme binding
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to human prion diseases
  • Variant & Polymorphism SNP SNP, rs12249854(A/T), located in a HECTD2 intron, influencing susceptibility to human prion diseases (Tank 2009)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS