| basic FUNCTION
| catalyzing the cross linking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds |
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may be involved in apoptosis |
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involved in several steps of wound healing |
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inhibits in cooperation with GPR56 melanoma tumor growth and metastasis |
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involved in corneal epithelial cell death after UVB |
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play an important role in controlling the deformability and fragility, and therefore lifespan of erythrocytes, in a number of pathophysiological situations |
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involved in signal transduction and, like two other TGs (TGM3 and TGM5), is able to bind and hydrolyze guanosine triphosphate  |
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multifunctional enzyme that has been implicated in the pathogenesis of neurodegenerative diseases, ischemia, and stroke |
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may play an important role in protecting against the delayed neuronal cell death in ischemia and stroke |
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may be involved in the development of schizophrenia |
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antiapoptotic mediator of HIF1A through modulating both apoptosis and survival pathways that may confer a selective growth advantage to tumor cells |
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inhibits CASP3 activity and activates NFKB1 pathway |
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involved in early onset diabetes type 2 |
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regulates levels of cellular GTP-bound Rac and actin cytoskeletal reorganization through direct inhibition of BcR GTP-ase activating activity |
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increased TGM2 expression can result in the induction of TGFB1 causing increased synthesis and deposition of matrix proteins |
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acts as a G-protein |
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inducing degradation of PP2A-alpha, thereby increasing MMP2 transcription |
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important extracellular crosslinking enzyme involved in matrix turnover and in bone differentiation |
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in vascular SMCs acts as a principal enhancer within the PDGF-BB/PDGFRB signaling axis involved in phenotypic modulation of these cells, thereby suggesting a novel role in the progression of vascular diseases |
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directly regulates hypoxic transcriptional machinery, but its interaction with HIF1B was not required for this regulation |
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may have intrinsic kinase activity that phosphorylates paxillin |
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roles of TGM2 in ADGRG1-mediated melanoma inhibition |
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is a calcium-dependent enzyme that irreversibly modifies proteins by forming cross-linked protein aggregates |
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because stress events activate the sympathetic nervous system and result in secretion of the catecholamines, adrenoceptor-mediated increase in macrophage TGM2 expression might be associated with stress-related inflammatory disorders |
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multifunctional protein cross-linking enzyme that has been implicated in apoptotic cell clearance but is also important in many other cell functions including cell adhesion, migration and monocyte to macrophage differentiation |
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expressed in mast cells recruited into skin or bone marrow, induces the development of pediatric mastocytosis |
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TGM2, likely in association with heparan sulphates, may exert its effect on apoptotic cell clearance via a mechanism involving the crosslinking of CD44 |
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is an important player in the biogenesis of exosomes controlling the selectivity of their cargo under stressful cellular conditions |
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catalyzes a crosslink between protein bound-glutamine and -lysine |
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multifunctional enzyme tissue Transglutaminase (TGM2) is known to participate in most of the monocyte- and macrophage-mediated processes |
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ubiquitous crosslinking enzyme present in both intra- and extracellular in many cell types and tissues |
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TGM2 functions include transamidation and GTPase activity, among others, and is implicated as a regulator of astrocytes migration |
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might contribute to early hepato-cellular carcinoma (HCC) recurrence through signaling pathways not related to epithelial-mesenchymal transition (EMT) and integrin signaling 9) |
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kidney fibrosis in aging may represent a natural outcome of upregulated COL18A1 and TGM2, but more likely it appears to be a result of cumulative stresses occurring on the background of synergistically acting geronic (aging) proteins, COL18A1 and TGM2 |
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TGM2 is involved in a broad range of cellular processes (including transmembrane signaling, mitochondrial functions, gene expression regulation, autophagy, and apoptosis) |
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has a pivotal role in celiac disease pathogenesis through generating immunogenic peptides from gliadin |
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TGM2 (and possibly also TGM3, TGM7) gained vital functions which have not been fully revealed, yet |
