protein
| at mitochondria, ULK1 interacts with FUNDC1, phosphorylating it at serine 17, which enhances FUNDC1 binding to MAP1LC3A |
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signaling pathway linking mitochondria-damaging signals to the dephosphorylation of FUNDC1 by PGAM5, which ultimately induces mitophagy |
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BCL2L1, interacts with and inhibits PGAM5, a mitochondrially localized phosphatase, to prevent the dephosphorylation of FUNDC1 at serine 13 (Ser13), which activates hypoxia-induced mitophagy |
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different mitophagy effectors, including the mitophagy receptors BNIP3L, BNIP3 and FUNDC1 and the PINK1/Parkin pathway, have been identified to participate in the selective clearance of mitochondria |
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FUNDC1 integrates mitochondrial fission and mitophagy at the interface of the MAM (ER-mitochondrial contact site (MAM)) by working in concert with DNM1L and CANX under hypoxic conditions in mammalian cells |
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FUNDC1, mediate selective removal of damaged or superfluous mitochondria through their specific interaction with MAP1LC3A |
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receptor for hypoxia-induced mitophagy in mammalian cells interacting with microtubule-associated protein light chain 3 beta (MAP1LC3B) through its LC3 interaction region (LIR) |
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mitochondrial E3 ligase MARCH5, plays a role in regulating hypoxia-induced mitophagy by ubiquitylating and degrading FUNDC1 |
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KLC1 may potentially compete with MAP1LC3A, a key component for autophagosome formation, to interact with FUNDC1 |
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FUNDC1 is a substrate of MARCH5, a mitochondrially localized E3 ubiquitin ligase |
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melatonin suppresses platelet activation and function against cardiac ischemia/reperfusion injury via PPARG/FUNDC1/mitophagy pathways |