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FLASH GENE
Symbol DEFB106B contributors: KTN/npt - updated : 27-01-2009
HGNC name defensin, beta 106B
HGNC id 28879
Location 8p23.1      Physical location : 7.340.025 - 7.686.575
Synonym name beta-defensin 6
Synonym symbol(s) BD6, DEFB-6, DEFB106, BD-6, DEFB6
DNA
TYPE functioning gene
SPECIAL FEATURE head to head, opposite orientation
text
  • duplication resulting in two identical copies of defensin, beta 106, DEFB106A and DEFB106B, in head-to-head orientation
  • representing the more telomeric copy
  • STRUCTURE 3.88 kb     2 Exon(s)
    MAPPING cloned Y linked N status confirmed
    Map pter - D8S1819 - D8S1706 - DEFB106B - D8S1825 - cen
    Authors UCSC (2009)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 303 - 65 - -
  • a 20 aa signal peptide of 2.3 kda
  • a 45 aa mature peptide of 5 kda
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemmale genital tractepididymis specific
    Respiratorylung   specific
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to rattus Defb15 (75.4 pc)
    homolog to murine Defb15 (75.4 pc)
    Homologene
    FAMILY
  • beta-defensin family
  • CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • acting as an antibacterial factor (Kao 2003)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS