basic FUNCTION
| integrin-associated signal transducer, marker of self on red blood cells |
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may play a role in membrane transport and/or signal transduction |
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may be involved in membrane permeability changes induced following virus infection |
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implicated in functions as diverse as neutrophil migration, promotion of neurite and filopodium formation by CD47, and T cell costimulation |
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its signaling can negatively affect the viability and function of cerebral endothelial cells |
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T cell-negative regulator of type 1 responses that may limit unwanted collateral damage to maximize protection and minimize host injuryv |
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may play an inhibitory role in NK cell-mediated cytotoxicity against cancer cells, implying a possible mechanism of immune escape in human cancer |
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role for CD47-dependent phagocyte-mediated mechanisms for the control of hematopoietic cell numbers |
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homeostatic regulatory role of CD47–SIRPA interactions in the context of antibody-mediated destruction of tumor cells by myeloid cells |