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FLASH GENE
Symbol CEP70 contributors: mct/npt/pgu - updated : 02-04-2010
HGNC name centrosomal protein 70kDa
HGNC id 29972
Location 3q22.3      Physical location : 138.213.188 - 138.313.129
Synonym name
  • p10-binding protein
  • Cep70 protein
  • Synonym symbol(s) BITE, FLJ13036
    DNA
    TYPE functioning gene
    STRUCTURE 99.94 kb     18 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 2678 69.62 597 - 2003 14654843
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid    
    Reproductivemale systemtestis  highly
     male systemprostate   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a putative HDAC (histone deacetylase) interacting domain
  • HOMOLOGY
    Homologene
    FAMILY
  • protein kinase PKN/PRK1 family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    text localizes to the centrosome throughout the cell cycle (centrosomal localization pattern is dependent on its interaction with TUBG1)
    basic FUNCTION
  • role in making the cilium and involved in determination of the length of the axoneme
  • plays a significant role in the organization of both preexisting and nascent microtubules in interphase cells
  • necessary for the organization and orientation of the bipolar spindle during mitosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with TUBG1 to localize at the centrosome and is critical for mitotic spindle assembly
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS