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FLASH GENE
Symbol CEP192 contributors: mct/npt/pgu - updated : 02-04-2013
HGNC name centrosomal protein 192kDa
HGNC id 25515
Location 18p11.21      Physical location : 12.991.360 - 13.125.049
Synonym symbol(s) KIAA1569, FLJ10352
DNA
TYPE functioning gene
STRUCTURE 116.55 kb     40 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
40 - 7995 - 2537 - 2003 14654843
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Hearing/Equilibriumear    
Lymphoid/Immunelymph node    
 thymus    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
HOMOLOGY
Homologene
FAMILY
  • leucine-rich-repeat (LRR) superfamily
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    basic FUNCTION
  • a major regulator of pericentriolar material recruitment, centrosome maturation, and centriole duplication
  • with pericentrin are mutually dependent for their localization to mitotic centrosomes during centrosome maturation
  • required for both centrosome maturation and spindle assembly thus providing a molecular link between these two processes
  • stimulates the formation of the scaffolding upon which gamma-tubulin ring complexes and other proteins involved in microtubule nucleation and spindle assembly become functional during mitosis
  • CEP192-mediated mechanism maximizes AURKA activity at centrosomes and appears essential for the function of these organelles as microtubule (MT)-organizing centers
  • targets AURKA to centrosomes and promotes activation of the dimerized enzyme
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • essential component of the maturation machinery
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • AURKA cofactor in centrosome-driven spindle assembly (targets AURKA to mitotic centrosomes where the locally accumulating AURKA forms homodimers or oligomers)
  • associates with NEDD1 and modulates its mitotic phosphorylation, and also may regulate spindle assembly by modulating NEDD1 function
  • promotes robust mitotic spindle assembly by regulating K63-polyubiquitin-mediated signaling through CYLD
  • EGLN2 function is required for centrosome duplication and maturation through modification of the critical centrosome component CEP192
  • CEP192 and CEP152 serve as two distinct scaffolds that recruit PLK4 to centrosomes in a hierarchical order, and competitively interacted with the cryptic polo box of PLK4 through their homologous N-terminal sequences containing acidic-alpha-helix and N/Q-rich motifs
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    results in the formation of multiple, extracentriolar foci of gamma-tubulin and pericentrin
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS