basic FUNCTION
| a major regulator of pericentriolar material recruitment, centrosome maturation, and centriole duplication |
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with pericentrin are mutually dependent for their localization to mitotic centrosomes during centrosome maturation |
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required for both centrosome maturation and spindle assembly thus providing a molecular link between these two processes |
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stimulates the formation of the scaffolding upon which gamma-tubulin ring complexes and other proteins involved in microtubule nucleation and spindle assembly become functional during mitosis |
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CEP192-mediated mechanism maximizes AURKA activity at centrosomes and appears essential for the function of these organelles as microtubule (MT)-organizing centers |
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targets AURKA to centrosomes and promotes activation of the dimerized enzyme |