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FLASH GENE
Symbol DUSP26 contributors: shn/npt - updated : 15-09-2009
HGNC name dual specificity phosphatase 26 (putative)
HGNC id 28161
Location 8p12      Physical location : 33.448.855 - 33.457.439
Synonym name
  • low-molecular-mass dual-specificity phosphatase 4
  • dual-specificity phosphatase SKRP3
  • CDNA FLJ31142 fis, clone IMR322001317, weakly similar to Homo sapiens protein phosphatase
  • mitogen-activated protein kinase phosphatase 8
  • dual specificity phosphatase SKRP3
  • novel amplified gene in thyroid anaplastic cancer
    • Synonym symbol(s) MGC1136, MGC2627, MKP8, LDP-4, NATA1, SKRP3, DUSP24, MKP8, DSP-4
    EC.number 3.1.3.16; 3.1.3.48
    DNA
    TYPE functioning gene
    STRUCTURE 8.59 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map pter - D8S1758 - D8S259 - DUSP26 - D8S1845 - D8S1709 - cen
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1665 23.9 211 Cerebellum, midbrain Takagaki et al 2007
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainhindbraincerebellum specific
    cell lineage
    cell lines IMR32
    fluid/secretion
    at STAGE
    Text Expressed in embryonal cancers and in anaplatic thyroid cancer
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a dual-specificity phosphatase domain that can dephosphorylate itself (Yu 2007)
    • HOMOLOGY
    interspecies ortholog to Dusp26, Mus musculus
    ortholog to Dusp26, Rattus norvegicus
    ortholog to DUSP26, Pan troglodytes
    Homologene
    FAMILY
  • protein-tyrosine phosphatase family
  • non-receptor class dual specificity subfamily
    • CATEGORY adhesion , tumor suppressor , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus
    basic FUNCTION
  • having a dual-specificity phosphatase domain that can dephosphorylate itself
  • may act as an oncogene in anaplastic thyroid cancer, and might be a useful diagnostic marker and therapeutic target of this disease
  • formed a physical complex with MAPK14, and promoted survival of anaplastic thyroid cancer cells by inhibiting MAPK14-mediated apoptosis (Yu 2007)
  • may be be involved in critical signaling events such as control of MAP kinases (Takagaki 2007)
  • Intracellular transport and cell –cell adhesion
  • dephosphorylates the Kap3 subunit of the KIF3 motor and
    • enhances N-cadherin-mediated cell–cell interactions
  • may have a tumor-suppressive function in brain tumors
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cell to cell transport
    text catalyses dephosphorylation of protein phospho-
    Ser/Thr and phospho-Tyr residues
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction with HSF4B places this transcription factor within a regulatory circuit in the MAP kinase signaling pathway
  • inactivates MAPK1 and MAPK3, inhibits MAP kinase p38 and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells
  • KIF3 and KAP3
    • cell & other
    REGULATION
    Other Dusp26 expression is downregulate in human brain tumors like glioblastoma
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in anaplastic thyroid cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target useful diagnostic marker and therapeutic target of anaplastic thyroid cancer
    ANIMAL & CELL MODELS