Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol HSD17B14 contributors: mct/npt - updated : 24-02-2009
HGNC name hydroxysteroid (17-beta) dehydrogenase 14
HGNC id 23238
Location 19q13.33      Physical location : 49.316.273 - 49.339.934
Synonym name
  • retinal short-chain dehydrogenase/reductase retSDR3
  • dehydrogenase/reductase (SDR family) member 10
  • 17-beta-hydroxysteroid dehydrogenase DHRS10
  • Synonym symbol(s) SDR3, DHRS10, SDR47C1, retSDR3
    EC.number 1.1.1.-
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 23.66 kb     9 Exon(s)
    regulatory sequence Binding site
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1277 28 270 - Lukacik (2007)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • short-chain dehydrogenases/reductases (SDR) family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • converting NAD+ into NADH in the presence of oestradiol, testosterone and 5-androstene-3beta, 17beta-diol (Lukacik 2007)
  • involved in the metabolism of a large variety of compounds, including steroid hormones, prostaglandins, retinoids, lipids and xenobiotics (Persson 2009)
  • may be playing a role in the local inactivation of steroids in the central nervous system and placenta (Lukacik 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS