Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CDCA7L contributors: mct - updated : 06-09-2016
HGNC name cell division cycle associated 7-like
HGNC id 30777
Location 7p15.3      Physical location : 21.940.517 - 21.985.542
Synonym name
  • transcription factor RAM2 splice variant c
  • transcription factor RAM2 splice variant b
  • Synonym symbol(s) RAM2, R1, JPO2
    DNA
    TYPE functioning gene
    STRUCTURE 45.03 kb     10 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 2922 - 454 - 2014 24634210
    9 - 2784 - 408 - 2014 24634210
    11 - 2976 - 420 - 2014 24634210
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumear   highly
    Lymphoid/Immunethymus   highly
    Reproductivemale systemtestis  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    intraspecies homolog to CDCA7
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • potentiating C-Myc transforming activity
  • inhibiting the MAOA promoter and enzymatic activities, and acting as a repressor in apoptotic signaling pathways
  • able to activate the extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathway and regulate the cell cycle, thus promoting hepatocellular carcinoma (HCC) progression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    apoptotic signaling pathways
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MycNTD binding protein, interacting with MYC
  • in the absence of PSIP1, CDCA7L performs chromatin scanning inherent to transcription factors
  • PSIP1 interactions with transcriptional repressor CDCA7L and domesticated transposase POGZ, and the POGZ interaction is nearly identical to the interaction of PSIP1 with KMT2A
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in medulloblastoma, with metastatic tumors
    constitutional     --over  
    in hepatocellular carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    may constitute a potential therapeutic target in HCC
    ANIMAL & CELL MODELS