basic FUNCTION
| downregulating HLA class II expression on the cell surface |
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may participate in providing a microenvironment at the tumor site insensitive to interferon-gamma stimulation and thus prevents an efficient local immune response |
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acting as as a regulatory protein, possibly involved in transcription |
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down-regulator of human leukocyte antigen (HLA) II |
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is a spindle pole-associated protein that colocalizes with MAD1L1 at the spindle poles in metaphase and anaphase |
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is required for kinetochore localization of MAD1L1, mitotic progression, and activation of the spindle assembly checkpoint (SAC) |
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has a role in the activation of the SAC and in mitosis progression |
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may play a crucial role in implantation, during pregnancy |