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FLASH GENE
Symbol PCP2 contributors: mct - updated : 13-03-2024
HGNC name Purkinje cell protein 2
HGNC id 30209
Location 19p13.2      Physical location : 7.696.508 - 7.698.570
Synonym name
  • Purkinje cell-specific protein L7
  • Synonym symbol(s) L7, GPSM4, FLJ27345, MGC41903, PCD5, DKFZp686M0187
    DNA
    TYPE functioning gene
    STRUCTURE 5.39 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 747 - 136 - 2008 18768681
    4 - 474 - 120 - 2008 18768681
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainhindbraincerebellum specific Homo sapiens
    Reproductivemale systemtestis  highly
    Visualeyeretina  highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiens
    NervousPurkinje cell Homo sapiens
    Visualbipolar cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    one GoLoco domain
    HOMOLOGY
    interspecies ortholog to murine Pcp2
    Homologene
    FAMILY GoLoco domain-containing family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    text localized in dendrites of neurons
    basic FUNCTION
  • may be playing a role in controlling the development and/or motor control function of Purkinje cells
  • is likely a guanine nucleotide dissociation inhibitor
  • PCP2 facilitates cation channels closure in the dark, shortens the rise time of the light response directly, and accelerates the decay time indirectly via the inhibitory network
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS