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FLASH GENE
Symbol TEF contributors: np/ - updated : 19-10-2005
HGNC name thyrotrophic embryonic factor
HGNC id 11722
Location 22q13.2      Physical location : 41.763.391 - 41.795.328
Synonym name thyrotroph embryonic factor
Synonym symbol(s) KIAA1655
DNA
TYPE functioning gene
STRUCTURE 31.94 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 4382 - 303 - -
4 - 4349 - 273 - -
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   highly
 thymus   highly
Digestiveliver    
endocrinebraindiencephalonpituitary  
Nervousbrain   highly
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Endocrinethyrotrophs
cell lineage
cell lines pituitary cell line
fluid/secretion
at STAGE
physiological period embryo
Text developing pituitary gland thyrotroph
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • proline and acidic AA rich,basic leucine zipper
  • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    intraspecies homolog to albumin D-box
    Homologene
    FAMILY
  • PAR (proline and acidic amino-acids rich) family
  • bZIP family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • expressed in kidney according to a robust circadian rhythm
  • transcription factor binding to and transactivating the TSHB promoter
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS circadian , development
    PATHWAY
    metabolism
    signaling hormonal
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS