Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PRMT3 contributors: mct - updated : 05-12-2023
HGNC name protein arginine methyltransferase 3
HGNC id 30163
Location 11p15.1      Physical location : 20.409.075 - 20.530.877
Synonym name
  • heterogeneous nuclear ribonucleoprotein methyltransferase-like 3
  • HMT1 hnRNP methyltransferase-like 3 (S. cerevisiae)
  • Synonym symbol(s) HRMT1L3
    EC.number 2.1.1.319
    DNA
    TYPE functioning gene
    STRUCTURE 121.62 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 2552 - 532 - 2023 36400311
    15 - 2416 - 454 - 2023 36400311
    14 - 2366 - 469 - 2023 36400311
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
    Respiratoryrespiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a C2H2-type zinc finger at the N-terminus
  • zinc-finger domain is necessary and sufficient for binding to RPS2
  • mono polymer homomer , monomer , dimer
    HOMOLOGY
    Homologene
    FAMILY protein arginine n-methyltransferase family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text only type I enzyme that is restricted to the cytoplasm
    basic FUNCTION
  • ribosomal protein methyltransferase that affects the cellular level of ribosomal subunits
  • regulating ribosome biosynthesis at a stage beyond pre-rRNA processing
  • catalysing the formation of asymmetric dimethylarginine
  • implicated in ribosomal function and in the regulation of protein synthesis
  • cytosolic enzyme that catalyzes the formation of mono- and asymmetric dimethyl arginines, with ribosomal protein (RP) S2 as its main in vivo substrate
  • expression of lipogenic proteins was increased by PRMT3 overexpression, but decreased by PRMT3 silencing
  • regulates protein functions by introducing asymmetric dimethylation marks at the arginine residues in proteins
  • PRMT3 could also regulate global gene expression through protein-protein interactions
  • crucial regulator in metabolic reprogramming and gene expression in cancers
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • RPS2 promotes likely the formation of a conserved extraribosomal complex with PRMT3 and PDCD2L
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with RPS2
  • Tyr87 is important for the interaction between PRMT3 and RPS2 and for its full enzymatic activity
  • SCN5A is post-translationally modified by arginine methylation, by PRMT3 and PRMT5
  • PRMT3 also increased the transcriptional activity of NR1H3 by directly binding with NR1H3 in a methylation-independent manner
  • PDCD2Lis a novel PRMT3-associated protein
  • ZNF277 and PRMT3 compete for RPS2 binding, because overexpression of PRMT3 inhibited the formation of the ZNF277-RPS2 complex
  • GAPDH is a PRMT3-binding protein and GAPDH is methylated at R248 by PRMT3
  • PRMT3 inhibits the enzymatic activity of ALDH1A1 and negatively regulates the expression of retinoic acid responsive genes in a methyltransferase activity independent manner
  • promotes tumorigenesis by methylating and stabilizing HIF1A in colorectal cancer
  • cell & other
    REGULATION
    inhibited by N-ethylmaleimide and high concentrations of zinc chloride
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    predicted poorer overall survival rate in patients with gliomas
    tumoral       gain of function
    in pancreatic cancer, and its expression is associated with poor survival
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS