basic FUNCTION
| ribosomal protein methyltransferase that affects the cellular level of ribosomal subunits |
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regulating ribosome biosynthesis at a stage beyond pre-rRNA processing |
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catalysing the formation of asymmetric dimethylarginine |
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implicated in ribosomal function and in the regulation of protein synthesis |
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cytosolic enzyme that catalyzes the formation of mono- and asymmetric dimethyl arginines, with ribosomal protein (RP) S2 as its main in vivo substrate |
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expression of lipogenic proteins was increased by PRMT3 overexpression, but decreased by PRMT3 silencing |
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regulates protein functions by introducing asymmetric dimethylation marks at the arginine residues in proteins |
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PRMT3 could also regulate global gene expression through protein-protein interactions |
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crucial regulator in metabolic reprogramming and gene expression in cancers |