Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ATAD2 contributors: mct - updated : 05-03-2011
HGNC name ATPase family, AAA domain containing 2
HGNC id 30123
Location 8q24.13      Physical location : 124.332.092 - 124.408.705
Synonym name
  • AAA nuclear coregulator cancer-associated protein
    • Synonym symbol(s) MGC5254, PRO2000, MGC29843, ANCCA
    DNA
    TYPE functioning gene
    STRUCTURE 76.61 kb     28 Exon(s)
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    28 - 5580 - 1390 - 2010 20581866
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node    
    Reproductivefemale systemuteruscervix  
     male systemtestis  highly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text liver
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • AAA type ATPase domain
  • a bromodomain
    • HOMOLOGY
    interspecies homolog to murine Atad2
    intraspecies homolog to ATAD2B
    Homologene
    FAMILY AAA ATPase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    basic FUNCTION
  • estrogen-regulated AAA+ ATPase coactivator for ESR1, and required for coregulator occupancy and chromatin modification
  • controls chromatin dynamics, genome transcriptional activities and apoptotic cell response
  • functions as a global regulator of chromatin structure and function
  • crucial for assembly of chromatin-modifying complexes and proliferation of hormone-responsive cancer cells
  • acts as a pioneer factor in E2F-dependent gene activation and this novel mechanism involving ATAD2 bromodomain may contribute to cancer cell proliferation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATB binding
    protein
  • target of estrogen in human breast cancer cells, and controls the estrogen-dependent expression of several ESR1 target genes
  • binds the MYC oncogene and stimulates its transcriptional activity
  • links the E2F and MYC pathways and contributes to the development of aggressive cancer through the enhancement of MYC-dependent transcription
  • direct target of oncogene AIB1/ACTR/SRC-3 and a transcriptional coregulator for estrogen and androgen receptors
    • cell & other
  • associates with chromosomes at late mitosis, and its occupancy at E2F targets peaks at the G(1)-to-S transition
    • REGULATION
    Other pRB-E2F pathway regulates ATAD2 expression, which is limiting for the entry into the S phase of the cell cycle
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    up-regulated in breast, uterus, colon, ovary, and stomach tumors
    tumoral     --over  
    in several cancer, and its high expression is a strong predictor of rapid mortality in lung and breast cancers
    tumoral     --over  
    in somatic cells, by acting on basic properties of chromatin, may contribute to malignant transformation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    intrinsic properties of its two domains, AAA-ATPase and bromodomain, could provide a basis for the development of therapeutic strategies specifically targeting ATAD2 in cancer
    cancerreproductivebreast
    prognostic marker and a therapeutic target for triple-negative cancers
    ANIMAL & CELL MODELS