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FLASH GENE
Symbol CDNF contributors: mct/npt - updated : 08-06-2015
HGNC name cerebral dopamine neurotrophic factor
HGNC id 24913
Location 10p13      Physical location : 14.861.250 - 14.879.983
Synonym name
  • conserved dopamine neurotrophic factor
  • arginine-rich, mutated in early stage tumors-like 1
  • Synonym symbol(s) ARMETL1
    DNA
    TYPE functioning gene
    STRUCTURE 18.73 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1330 21 187 - 2007 17611540
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas    
    Nervousbrainhindbraincerebellum   Homo sapiens
     brainforebraincerebral cortex   Homo sapiens
     brainbasal nucleistriatum   Homo sapiens
     brainlimbic systemhippocampus   Homo sapiens
     brainmidbrainsubstantia nigra   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal domain saposin-like lipid-binding domain (Parkash 2009)
  • HOMOLOGY
    Homologene
    FAMILY
  • ARMET family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    text may thus bind lipids or membranes (Parkash 2009)
    basic FUNCTION
  • protects and repairs midbrain dopaminergic neurons (Parkash 2009)
  • novel neurotrophic factor with strong trophic activity on dopaminergic neurons comparable to that of glial cell line-derived neurotrophic factor (GDNF)
  • alleviates ER stress-induced astrocyte damage
  • plays an important role in astrocyte inflammation and functioning by resisting ER stress
  • MANF and CDNF can protect cells during endoplasmic reticulum (ER) stress
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to Parkinson disease (PD)
    Variant & Polymorphism C allele of an intronic CDNF SNP (rs7094179) might be an allele for susceptibility to PD
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurologyneurodegenerative 
    overexpression of CDNF in astrocytes shows the potential to alleviate cell damage and proinflammatory cytokine secretion, which may represent a promising strategy for neuroprotection in the CNS
    ANIMAL & CELL MODELS