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FLASH GENE
Symbol ALDH1L2 contributors: mct - updated : 23-12-2010
HGNC name aldehyde dehydrogenase 1 family, member L2
HGNC id 26777
Location 12q23.3      Physical location : 105.413.563 - 105.478.341
Synonym name mitochondrial 10-formyltetrahydrofolate dehydrogenase
Synonym symbol(s) FLJ38508, MGC119536, MGC119537, DKFZp686M064, DKFZp686A16126, FLJ36769, DKFZp686P14145, mtFDH
EC.number 1.5.1.6
DNA
TYPE functioning gene
STRUCTURE 64.78 kb     23 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
23 - 7555 101.6 923 - 2010 20498374
EXPRESSION
Rna function mRNA is most highly expressed in pancreas, heart, and brain
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Skin/Tegumentskin    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • extra N-terminal sequence of 22AAs, predicted to be a mitochondrial translocation signal, lacking negatively charged amino acids and enriched with positively charged residues (five arginines and two lysines), a characteristic of a mitochondria-targeting peptide
  • HOMOLOGY
    interspecies ortholog to murine Aldh1l2
    Homologene
    FAMILY
  • aldehyde dehydrogenase family
  • ALDH1L subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • having dehydrogenase/hydrolase activities similar to cytosolic FDH (ALDH1L1
  • mitochondrial enzyme, a likely source of CO2 production from 10-formyltetrahydrofolate in mitochondria and playing an essential role in the distribution of one-carbon groups between the cytosolic and mitochondrial compartments of the cell
  • possesses 10-fTHF dehydrogenase/hydrolase activities
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS