basic FUNCTION
| may be implicated in proliferation and activation of lymphocytes and monocytes |
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is a mammalian protein required for the import of the antibiotic blasticidin S |
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LRRC8D-containing VRACs are crucial for cell volume regulation by an important organic osmolyte and may influence cisplatin/carboplatin responsiveness of tumors |
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was crucial for the translocation of overall neutral compounds like myo-inositol, taurine and GABA, and sustained the transport of positively charged lysine |
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LRRC8A/D-containing permeability pathway appears to dominate the release of uncharged osmolytes, while an alternative channel (or channels) is composed of LRRC8A/C/D/E and responsible for the loss of charged molecules |
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LRRC8D/VRAC anion channels enhance beta-cell glucose sensing and insulin secretion |
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pore-forming component of the volume-regulated anion channel (VRAC) |
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LRRC8A and LRRC8D have been implicated in the proliferation, migration, death, and multidrug resistance of cancer cells through their involvement in various signal pathways |