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FLASH GENE
Symbol BRINP3 contributors: mct - updated : 25-09-2014
HGNC name bone morphogenetic protein/retinoic acid inducible neural-specific 3
HGNC id 22393
Location 1q31.1      Physical location : -
Synonym name
  • DBCCR1-like protein 1
  • protein FAM5C
  • family with sequence similarity 5, member C
  • Synonym symbol(s) DBCCR1L, DBCCR1L1, RP11-445K1.1, FAM5C
    DNA
    TYPE functioning gene
    STRUCTURE 380.34 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2742 - 664 - 2017 28351617
    8 - 2884 - 766 - 2017 28351617
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   predominantly
    Reproductivefemale systembreastmammary gland moderately
     male systemprostate  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell Homo sapiens
    Skeletonosteoblast Homo sapiens
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains MACPF domain
    HOMOLOGY
    interspecies ortholog to rattus Brinp3
    Homologene
    FAMILY BRINP family
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • localized to the mitochondria
  • basic FUNCTION
  • possible physiological functions of BRINP family members in the development of the nervous system
  • potential role for this molecule in smooth muscle cell proliferation and senescence
  • may be a novel tumor suppressor gene (TSG) in tongue squamous cell carcinoma
  • contributes to aggressive periodontitis
  • enhances osteoblast differentiation in differentiated osteoblasts, and the effects of the conditioned medium from BRINP3-modulated myoblastic cells were positively correlated with the effects of BRINP3 on osteoblast phenotype in osteoblasts
  • having an important role in the proliferation and senescence of cells
  • may be an important humoral bone anabolic factor produced by muscle cells
  • might be an important humoral bone anabolic factor produced from muscle cells
  • has an anabolic effect in differentiated osteoblasts, although it suppresses the differentiation of myoblasts into osteoblasts
  • in endothelial cells, when BRINP3 is upregulated in response to inflammatory stimuli, it increases the expression of leukocyte adhesion molecules by increasing ROS production and NFKB1 activity
  • contributes to the TNF-induced expression of leukocyte adhesion molecules in vascular endothelial cells (ECs)
  • is an N-glycosylated protein and N-glycosylation is necessary for the secretion of BRINP3
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction of BRINP3 with UDP-glucose:glycoprotein glucosyltransferase 1 (UGGT1), a glycoprotein folding-sensor enzyme
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    FAM5C mRNA expression was significantly higher in aggressive periodontitis
    Susceptibility
  • to myocardial infarction
  • to peri-implantitis, independently from the presence of chronic periodontitis
  • Variant & Polymorphism SNP
  • BRINP3 polymorphic variant rs1342913 and low level of BRINP3 expression are associated with peri-implantitis, independently from the presence of chronic periodontitis
  • Candidate gene
    Marker
  • hypermethylated BRINP3 and MYLK can be used as potential biomarkers for diagnosis and pre-warning of gastric cancer
  • Therapy target
    ANIMAL & CELL MODELS