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FLASH GENE
Symbol DNTTIP2 contributors: - updated : 03-04-2006
HGNC name deoxynucleotidyltransferase, terminal, interacting protein 2
HGNC id 24013
Location 1p22.1      Physical location : 94.335.337 - 94.344.742
Synonym name
  • acidic 82 kDa protein mRNA
  • ERalpha binding protein
  • estrogen receptor binding protein
    • Synonym symbol(s) HSU15552, LPTS-RP2, RP4-561L24.1, ERBP, TdIF2
    DNA
    TYPE functioning gene
    STRUCTURE 9.00 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
    Endocrinepancreas   highly
    Lymphoid/Immunethymus   highly
    Respiratoryrespiratory tractlarynx  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two ESR1 binding regions
  • C-terminal ESR1 binding region is increased by estrogen while the binding of ERBP region at N-terminus is not affected by estrogen
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY receptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION enhancing the transcriptional activity of ESR1
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • bound to PPARG, RXRA, and ESR2
  • interacting with the DNA binding domain and the hinge region of ESR1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS