Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol HRNR contributors: mct - updated : 16-05-2018
HGNC name hornerin
HGNC id 20846
Location 1q21.3      Physical location : 152.184.557 - 152.196.669
Synonym name
  • intermediate filament-associated protein
  • filaggrin family member 3
  • Synonym symbol(s) S100a18, S100A16, FLG3
    DNA
    TYPE functioning gene
    STRUCTURE 12.12 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    regionally located . mapped between trichohyalin and filaggrin
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 9632 - 2850 - 2017 28916756
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemovary   
     male systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier liningepidermis   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentcornified cell Homo sapiens
    Skin/Tegumentkeratinocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two EF-hand calcium-binding domains
  • HOMOLOGY
    interspecies homolog to murine Hrnr
    homolog to drosophila prc
    Homologene
    FAMILY
  • S100-fused protein family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    intracellular,nucleus
    text
  • keratohyalin granules in the granular cells of the epidermis
  • in the epidermis, HRNR was detected at the periphery of keratohyalin granules in the upper granular layer and at the corneocyte periphery in the whole cornified layer
  • basic FUNCTION
  • having a function similar to but distinct from that of filaggrin in cornification
  • dispensable for acquisition of thermotolerance and does not play a significant role in recovery or protection of cells from acute heat shock
  • is a component of cornified cell envelopes of human epidermis
  • potential role in inflammatory/immune response or proliferation
  • role in the control of mammary cell function and breast cancer
  • shares numerous features with filaggrin, a key contributor to the epidermal barrier functions
  • is a regulator of tumor vascularity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • CAPN1 may be involved in the proteolytic processing of HRNR, because CAPN1 was co-located with HRNR in the cytoplasm of granular keratinocytes
  • cell & other
    REGULATION
    induced by DNA lesions or heat-shock stress
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --other  
    expressed in psoriatic skin
    tumoral     --over  
    on pancreatic tumor endothelium in a vascular endothelial growth factor (VEGF)-independent manner
    Susceptibility to atopic dermatitis (AD)
    Variant & Polymorphism SNP associated to atopic dermatitis (AD)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS