Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | NOXA1 | contributors: mct - updated : 25-01-2011 |
HGNC name | NADPH oxidase activator 1 |
HGNC id | 10668 |
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Location | 9q34.3 Physical location : 140.317.846 - 140.328.857 |
Synonym name | |
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Synonym symbol(s) | p51NOX, FLJ25475, NY-CO-31, SDCCAG31, MGC131800, p51NOX |
DNA |
TYPE | functioning gene |
STRUCTURE | 11.01 kb 14 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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MAPPING | cloned | Y | linked | N | status | provisional |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type | restricted |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||
organ(s) |
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cell lineage
cell lines
| fluid/secretion
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at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
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HOMOLOGY |
intraspecies | homolog to p67-phox |
Homologene |
FAMILY | |
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CATEGORY | regulatory |
SUBCELLULAR LOCALIZATION | intracellular |
intracellular,cytoplasm,cytosolic |
basic FUNCTION | |
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CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism |
signaling |
a component |
INTERACTION |
DNA |
RNA |
small molecule |
protein | |
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cell & other |
REGULATION |
Other | phosphorylation of NOXA1 is a part of the feedback mechanism that functions through activation of Rac with a net outcome of negative modulation of NOX1 activity |
ASSOCIATED DISORDERS |
corresponding disease(s) |
Susceptibility |
Variant & Polymorphism
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Candidate gene
Marker
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ANIMAL & CELL MODELS |
NoxA1 expression was significantly increased in aortas and atherosclerotic lesions of ApoE(-/-) mice compared with age-matched wild-type mice |