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FLASH GENE
Symbol KCNJ4 contributors: mct - updated : 27-10-2012
HGNC name potassium inwardly-rectifying channel, subfamily J, member 4
HGNC id 6265
Location 22q13.1      Physical location : 38.822.332 - 38.851.203
Synonym symbol(s) HIR, HIRK2, HRK1, IRK-3, IRK3, Kir2.3
DNA
TYPE functioning gene
STRUCTURE 28.87 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map cen - GCAT - GALR3 - POLR2F - SOX10 - PICK1 - PLA2G6 - MAFF - CSNK1E - KCNJ4 - DDX17 - KDELR3 - DMC1 - GTPBP1 - D22S272 - DNAL4 - NPTXR - CBX6 - CBX7 - PDGFB - RPL3 - SYNGR1 - D22S1155 - MAP3K7IP1 - ATF4 - CACNA1I - D22S428 - qter
Authors Dunham (99)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 2075 - 445 - 2002 11997254
2 - 1913 - 445 - 2002 11997254
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Nervousbrainforebrain  highly Homo sapiens
Olfactory (smell)olfactory bulb     Mus musculus
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two membrane-spanning domains
  • an amphipatic region pore, including the P domain with the K+ channel signature and an ATP-binding regulatory domain
  • C-terminal KCNJ4-peptide binds much more strongly to TAX1BP3 than to mammalian LIN7A, LIN7B, LIN7C, indicating that TAX1BP3 can compete with mammalian LIN7 to uncouple KCNJ4 from its basolateral membrane anchoring complex
  • mono polymer homomer , tetramer
    HOMOLOGY
    Homologene
    FAMILY potassium channel subfamily J
    CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • potassium non voltage-gated channel,inwardly rectifying
  • KCNJ4- channels are marked for clathrin-dependent internalization from the plasma membrane by a novel TFAP2A-dependent signal
  • heteromeric assemblies of KCNJ2, KCNJ12 and KCNJ4 channels underly membrane potential stabilizing currents in ventricular myocytes, neurons and skeletal muscle
  • specifically targeted on the basolateral membranes of epithelial and neuronal cells, and it thus plays an important role in maintaining potassium homeostasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • EDN1 inhibits human cardiac I(K1) current via a PKC-mediated phosphorylation of KCNJ12 channel subunits and additional regulatory effects on KCNJ4 channels
  • TAX1BP3 binding to KCNJ4 with a high affinity, causing the intracellular accumulation of KCNJ4 in cultured epithelial cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS