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FLASH GENE
Symbol FAM102A contributors: mct - updated : 23-05-2018
HGNC name family with sequence similarity 102, member A
HGNC id 31419
Location 9q34.11      Physical location : 130.702.860 - 130.742.812
Synonym name
  • early estrogen-induced gene 1
  • chromosome 9 open reading frame 132
  • sym-3 homolog A
  • Synonym symbol(s) EEIG1, C9orf132, bA203J24.7, MGC50853, C9orf132, SYM-3A
    DNA
    TYPE functioning gene
    STRUCTURE 39.95 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 4161 - 384 - 2013 23478294
    8 - 3643 - 242 - 2013 23478294
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas   highly
    Lymphoid/Immunelymph node   highly
    Reproductivemale systemprostate   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    intraspecies paralog to SKAP1
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • expression of EEIG1 protein occurs predominantly in the cytoplasm
  • basic FUNCTION
  • playing a role in estrogen action
  • positively regulates TNFSF11-induced osteoclast formation, likely due to its ability to facilitate TNFSF11-stimulated PLCG2 phosphorylation and NFATC1 induction
  • is a novel TNFRSF11A signaling component that is required for osteoclastogenesis
  • FAM102A plays a critical role in TNFRSF11A-induced osteoclast differentiation, and its role may be closely related to the induction of NFATC1
  • important role of EEIG1 in osteoclast differentiation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • FAM102A is a novel TNFRSF11A signaling component controlling TNFRSF11A-mediated osteoclast formation
  • TNFRSF11A-FAM102A signaling complex is necessary for PLCG2 phosphorylation that is required for the induction of NFATC1
  • FAM102A is a new interactor of SKAP2 (FAM102A adaptor interacts with the SH3 domain of SKAP2 by a binding motif containing Pro149)
  • FAM102A protein interacts with SKAP1 protein, a paralog of SKAP2 mainly expressed in hematopoietic cells
  • cell & other
    REGULATION
    induced by by 17 beta-estradiol
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    osteoarticularbone 
    might represent a new therapeutic strategy for the treatment of pathological bone resorption
    ANIMAL & CELL MODELS