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FLASH GENE
Symbol B4GALNT3 contributors: SGE - updated : 27-07-2010
HGNC name beta-1,4-N-acetyl-galactosaminyl transferase 3
HGNC id 24137
Location 12p13.33      Physical location : 569.542 - 671.058
Synonym name
  • beta 1,4-N-acetylgalactosaminyltransferase-transferase-III
  • beta4GalNAc-T3
  • N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-
  • acetylgalactosaminyltransferase
    Synonym symbol(s) FLJ40362, FLJ16224, B4GALNAC-T3
    EC.number 2.4.1.244
    DNA
    TYPE functioning gene
    STRUCTURE 101.52 kb     20 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 3438 - 998 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
     stomach   highly
    Reproductivemale systemtestis  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text kidney
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal transmembrane domain
  • four potential N-glycosylation sites
  • a DXH sequence thought to participate in divalent cation binding
  • a C-terminal WGGED motif (Sato 2003)
  • HOMOLOGY
    interspecies homolog to murine B4galnt3 (84.7pc)
    homolog to rattus B4galnt3 (83.5pc)
    Homologene
    FAMILY
  • chondroitin N- acetylgalactosaminyltransferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • could transfer GalNAc residues, producing N, N'-diacetylgalactosediamine structures at least in N-glycans and probably in both N- and O-glycans
  • up-regulation of B4GALNT3 may contribute to the malignant behavior of colon cancer cells (Huang 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    overexpressed in colon cancer cell line, enhancing cell-extracellular matrix adhesion, migration, anchorage-independent growth and invasion (Huang 2007)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS