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FLASH GENE
Symbol PARP10 contributors: - updated : 13-12-2006
HGNC name poly (ADP-ribose) polymerase family, member 10
HGNC id 25895
Location 8q24.3      Physical location : 145.051.320 - 145.060.635
Synonym symbol(s) FLJ14464
DNA
TYPE functioning gene
SPECIAL FEATURE opposite orientation
text head-to-tail arrangement with PLEC1
STRUCTURE 9.00 kb     11 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth   highly
 salivary gland   highly
Lymphoid/Immunespleen   highly
 thymus   highly
Reproductivefemale systemuteruscervix  
Respiratoryrespiratory tracttrachea  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a poly(ADP-ribose) polymerase domain, capable of ADP-ribosylating PARP-10 itself and core histones, but neither Myc nor Max
  • an RNA recognition motif and two ubiquitin interaction motifs
  • domains with homology to RNA recognition motifs and to poly(ADP-ribose) polymerases (PARP)
  • HOMOLOGY
    interspecies homolog to murine Parp10
    Homologene
    FAMILY PARP family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleolus
    text localized to the nuclear and cytoplasmic compartments that is controlled at least in part by a Leu-rich nuclear export sequence (NES)
    basic FUNCTION
  • Myc-interacting protein with poly(ADP-ribose) polymerase activity, involved in the control of cell proliferation
  • functioning in cell proliferation and may serve as a marker for proliferating cells
  • only nucleolar form acquires CDK-dependent phosphorylation through late-G1 to S phase, and from prometaphase to cytokinesis in the nucleolar organizing regions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacts with Myc
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS