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FLASH GENE
Symbol ZDHHC21 contributors: mct - updated : 28-12-2021
HGNC name zinc finger, DHHC-type containing 21
HGNC id 20750
Location 9p22.3      Physical location : 14.611.069 - 14.693.480
Synonym symbol(s) DHHC-21, DHHC21, DNZ1, HSPC097
EC.number 2.3.1.225
DNA
TYPE functioning gene
STRUCTURE 76.00 kb     10 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 9034 - 236 - 2016 27653213
10 - 8952 - 168 - 2016 27653213
10 - 9121 - 265 - 2016 27653213
11 - 9195 - 265 - 2016 27653213
11 - 9228 - 265 - 2016 27653213
11 - 9115 - 168 - 2016 27653213
11 - 9284 - 265 - 2016 27653213
11 - 9009 - 168 - 2016 27653213
11 - 9178 - 265 - 2016 27653213
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Lymphoid/Immunethymus   predominantly
Reproductivemale system    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Muscular    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
DHHC-type zinc finger
HOMOLOGY
interspecies ortholog to murine Zdhhc21
Homologene
FAMILY ZDHHC family of protein acyl transferases
CATEGORY enzyme , transcription factor
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum
intracellular,cytoplasm,organelle,Golgi
text integral membrane protein
basic FUNCTION
  • ZDHHC7 and ZDHHC21 proteins are novel targets to selectively inhibit membrane sex steroid receptor localization and function
  • ZDHHC17, ZDHHC18, ZDHHC20, and ZDHHC21 exhibited weak or moderate activities
  • is a ZDHHC isoform affecting vascular function and implicated in a novel molecular mode of regulation of vascular tone and blood pressure
  • can play an essential role in regulation of T cell-mediated immunity
  • is an essential component of the T cell receptor signaling machinery
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    Zn2+
    protein
  • potential involvement of ZDHHC21-mediated PLCB1 palmitoylation in endothelial inflammation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS