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FLASH GENE
Symbol ARHGEF26 contributors: mct - updated : 15/11/2008
HGNC name Rho guanine nucleotide exchange factor (GEF) 26
HGNC id 24490
Location 3q25.2      Physical location : 153.839.148 - 153.975.616
Synonym name
  • Src homology 3 domain-containing guanine nucleotide exchange factor
  • SH3-containing guanine nucleotide exchange factor
  • Synonym symbol(s) CSGEF, HMFN1864, DKFZP434D146, SGEF
    DNA
    TYPE functioning gene
    STRUCTURE 136.47 kb     15 Exon(s)
    regulatory sequence Promoter
    Binding site   HRE
    text structure
  • an alternate androgen-responsive promoter
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 splicing 5181 97 871 ubiquitous PMID: 15133129
  • Dbl homology and pleckstrin homology domains
  • an N-terminal proline-rich domain
  • a C-terminal Src homology 3 domain
  • two nuclear localization signals
  • acting as a regulator of Rho guanosine triphosphatases
  • - splicing 3106 15 139 . restricted to prostate and liver . up-regulated by androgens in LNCaP cells . Up-regulation sensitive to actinomycin D . expression controlled by an alternate androgen-responsive promoter of the SGEF gene PMID: 15133129
  • also called CSGEF
  • 1 SH3 domain
  • N-terminally truncated form of SGEF designated C-terminal SGEF (CSGEF)
  • functioning as an androgen-induced regulator of Rho guanosine triphosphatase activity in epithelial cells of the human prostate
  • EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Nervousbrain   moderately
    Reproductivemale systemprostate  highly
     male systemtestis  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestivehepatocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • proline-rich N-terminus required to generate dorsal, but not lateral, membrane ruffles
  • a functional SH3 domain required to colocalize with filamentous actin at sites of membrane protrusion
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • involved in regulation of Rho guanosine triphosphatases
  • stimulated the formation of large interconnected membrane ruffles across dorsal surfaces when expressed in fibroblasts
  • a RhoG exchange factor that regulate membrane dynamics in promotion of macropinocytosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    new signaling pathway involving RHOG and its exchange factor SGEF downstream from ICAM1 that is critical for leukocyte trans-endothelial migration
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with RHOG (both SGEF and RhoG regulate membrane dynamics in promotion of macropinocytosis)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS