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FLASH GENE
Symbol TANC1 contributors: npt/mct - updated : 04-02-2009
HGNC name tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
HGNC id 29364
Location 2q24.2      Physical location : 159.825.145 - 160.089.168
Synonym name
  • TPR domain, ankyrin-repeat and coiled-coil-containing
  • rolling pebbles homolog B (Drosophila)
  • TANC1 protein
  • Synonym symbol(s) KIAA1728, TANC, ROLSB
    DNA
    TYPE like-sequence
    STRUCTURE 264.02 kb     27 Exon(s)
    regulatory sequence
    MAPPING cloned Y linked N status provisional
    Map cen - D2S1649E - D2S258 - TANC1 - D2S1500E - D2S1731E - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    27 - 7644 - 1861 - Suzuki (2005)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
    Endocrineneuroendocrinepituitary  highly
    Hearing/Equilibriumear   highly
    Reproductivefemale systembreastmammary gland  
     female systemuterus   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three tetratricopeptide repeats (TPRs)
  • ten ankyrin repeats
  • a coiled-coil region
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • working as a postsynaptic scaffold component by forming a multiprotein complex with various postsynaptic density proteins
  • scaffold protein that interacts with various postsynaptic scaffold and cytoskeletal proteins, including PSD-95 and SAP97)(Nonaka 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with TNIK and MINK1 (induced phosphorylation of TANC1)(Nonaka 2008)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS